Ideas

We share our ideas openly. Here are some of the ways to follow us.

Follow our team on Twitter

Visit our Socials page to follow the investment team as they think-out-loud.

Socials

Subscribe to our newsletter

We send out the latest thinking very couple of weeks in our newsletter

Newsletter

Podcast

When our Partner Mike Nicholls gets a moment, he makes the Science Meets VC podcast.

Podcast

Our latest thinking

Building Out Loud #4: Chat GPT4 is your Venture Science Co-Pilot for imagining new companies
April 4, 2023
Building Out Loud #4: Chat GPT4 is your Venture Science Co-Pilot for imagining new companies
Loam Bio: Giga-ambition to take on Planetary Challenges…
February 19, 2023
Loam Bio: Giga-ambition to take on Planetary Challenges…
The Venture Science Canvas: my ‘napkin’ for starting a new company with advantage
February 25, 2022
The Venture Science Canvas: my ‘napkin’ for starting a new company with advantage
A sprinkle of venture pixie dust
November 19, 2021
A sprinkle of venture pixie dust
Regrow: Doubling Down on Markets and Founders
August 22, 2021
Regrow: Doubling Down on Markets and Founders
When VCs say 'No'
July 27, 2021
When VCs say 'No'
Ep149 – Phil Morle (Partner – Main Sequence Ventures) on leaps, equity and the art of flearning
May 27, 2021
Ep149 – Phil Morle (Partner – Main Sequence Ventures) on leaps, equity and the art of flearning
A letter to our new team members (we can’t wait to find out who you are…)
May 18, 2021
A letter to our new team members (we can’t wait to find out who you are…)
Curious
May 18, 2021
Curious
The Next Leap in Solving The World’s Greatest Challenges: Our $250m Fund 2
May 1, 2021
The Next Leap in Solving The World’s Greatest Challenges: Our $250m Fund 2
Using ‘Venture Science’ for faster, deeper R&D
March 16, 2021
Using ‘Venture Science’ for faster, deeper R&D
Religion is a culture of faith; science is a culture of doubt
March 6, 2021
Religion is a culture of faith; science is a culture of doubt
What It Takes to Lead a Deep Tech Company: Hear from 3 Amazing Founders
March 5, 2021
What It Takes to Lead a Deep Tech Company: Hear from 3 Amazing Founders
Jargons that VCs use, translated
May 21, 2020
Jargons that VCs use, translated
China’s Tech Scene during the Coronavirus Outbreak
February 4, 2020
China’s Tech Scene during the Coronavirus Outbreak
Unlock the magical differences in your team with a ‘User Guide of You’
January 1, 2020
Unlock the magical differences in your team with a ‘User Guide of You’
Startup to VC: My First Month at Main Sequence Ventures
September 27, 2019
Startup to VC: My First Month at Main Sequence Ventures
The Founder’s Secret Weapon: Listening
October 6, 2018
The Founder’s Secret Weapon: Listening
The Flow of Science and Commercialisation
March 28, 2018
The Flow of Science and Commercialisation
Listen: Bill Bartee on Open the Pod Bay Doors podcast
September 11, 2017
Listen: Bill Bartee on Open the Pod Bay Doors podcast
NOVA: your chance to be a Deeptech VC
August 23, 2017
NOVA: your chance to be a Deeptech VC
Joining Main Sequence Ventures
July 24, 2017
Joining Main Sequence Ventures
A New Mission
June 7, 2017
A New Mission

Share your ideas

Pitch to Main Sequence

We're excited to hear about what you are building. If we invite you to come and pitch, be comfortable.

Pitch

Researcher Office Hours

Chat with us about commercialising your ideas. The Main Sequence team is running monthly office hours with researchers on commercialization.

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